6/26/2023 0 Comments She remains solavantDespite widespread contamination and increasing industrial, commercial, and military use, clinical investigations of TCE and PD have been limited. The molecule, like radon, evaporates from underlying soil and groundwater and enters homes, workplaces, or schools, often undetected. TCE pollutes outdoor air, taints groundwater, and contaminates indoor air. In multiple animal studies, the chemical reproduces the pathological features of PD.Įxposure is not confined to those who work with the chemical. In addition, a small epidemiological study found that occupational or hobby exposure to the solvent was associated with a 500% increased risk of developing PD. Since then, four case studies involving eight individuals have linked occupational exposure to TCE to PD. ![]() The colorless chemical was first linked to parkinsonism in 1969. ![]() TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). Other, less visible factors must be at play. However, these causes or risk factors do not account for the majority of cases. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. The etiologies of Parkinson’s disease (PD) remain unclear. Journal: Journal of Parkinson's Disease, vol. Keywords: Air pollution, indoor air pollution, environment, Parkinson’s disease, solvents, tetrachloroethylene, trichloroethylene, water pollution, chemical water pollution Note: These authors contributed equally to this work. | Division of Occupational and Environmental Medicine, San Francisco Veterans Affairs Health Care System, School of Medicine, University of California–San Francisco, San Francisco, CA, USAĬorrespondence to: Ray Dorsey, MD, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420694, Rochester, NY 14642, USA. Weill Institute for Neurosciences, Department of Neurology, University of California-San Francisco, San Francisco, CA, USAĬenter for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA ![]() Radboud University Medical Centre Donders Institute for Brain, Cognition and Behaviour Department of Neurology Centre of Expertise for Parkinson & Movement Disorders Nijmegen, the Netherlands | cĬenter for Health + Technology, University of Rochester Medical Center, Rochester, NY, USAĭepartment of Neurology, University of Rochester Medical Center, Rochester, NY, USA a b | Kieburtz, Karl a b | Tanner, Caroline M. a | Kinel, Dan a b | Frissen, Myrthe c | Schneider, Ruth B. Ray a b 1 * | Zafar, Maryam a 1 | Lettenberger, Samantha E.
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